Kailash Biosciences is a supplier of the SmartCompounds library to biomedical researchers. It offers compounds that have been approved by regulatory agencies, along with a unique search engine that helps scientists discover new uses for existing drugs.
Famous drug hunter and Nobel prizewinner Sir James Black stated that "the most fruitful basis for the discovery of a new drug is to start with an old drug.”1 The problem is that many approved drugs are no longer marketed or manufactured. And those that are available are often of inconsistent quality, with long lead times, forbidding prices, and impractical minimum order quantities.
Sir James' ideas are attracting renewed interest as new drugs become scarce and those that reach the market carry hefty prices that often exceed $100,000 per year, per course of treatment. There is compelling evidence that many existing drugs can be used—or repurposed—outside their original therapeutic area and deliver much-needed clinical value (Table 1). Indeed, for poorly treated diseases, half of prescriptions written are for off-label uses.2 And some scientists affirm that the majority of past therapeutic innovations have come not from the labs of industry, but from physicians treating patients for whom no approved therapy works and customizing treatments using drugs approved for other purposes.3
Kailash empowers the scientists who wish to follow Sir James' advice by helping them repurpose existing drugs or create improved variations that outperform approved therapies.
|Name||Original indication||Repurposed indications|
|Thalomid||Morning sickness||Multiple myeloma, leprosy|
|Botox||Wrinkles||Incontinence, migraine, cervical dystonia, sweating, blepharospasm, strabismus, muscle spasticity|
|Viagra||Erectile dysfunction||Pulmonary hypertension|
|Baclofen||Muscle relaxation||Alcohol addiction|
|Humira||Rheumatoid arthritis||Crohn's disease|
|Colcrys||Gout||Familial Mediterranean fever (rare)|
|Cyclobenzaprine||Muscle relaxation||Fibromyalgia, post-traumatic stress disorder|
|Chlorpromazine||Schizophrenia||Emesis, porphyria (rare), tetanus|
1 Raju, T.N. (1988). The Nobel chronicles: James Whyte Black, (b 1924), Gertrude Elion (1918–99), and George H. Hitchings (1905–98). Lancet 355, 1022 (2000).
2 Demonaco, H. J., Ali, A., & von Hippel, E. (2006). The major role of clinicians in the discovery of off-label drug therapies. Pharmacotherapy, 26(3), 323-32. doi: 10.1592/phco.26.3.323.
3 An open-source shot in the arm. The Economist (12 June 2004).